Dr. Andrew Karanas
The Face of General Surgery

Whether you come through the emergency department or schedule an elective procedure, SSM Health Medical Group now has a highly experienced, board certified general surgeon available to guide you toward healing and a better quality of life. Meet Dr. Andrew Karanas who joined SSM Health Medical Group in October of 2023. 

Growing up in New York, Dr. Karanas received his undergraduate degree  from Cornell University and his Doctor of Medicine degree from Columbia University Vagelos College of Physicians and Surgeons. He then completed his general surgery residency at the University of Rochester’s Strong Memorial Hospital in Rochester, NY.

While practicing as a general surgeon and trauma surgeon at DePaul  Hospital, he also held leadership positions by serving as vice president of medical affairs for two years and the trauma medical director for 12 years.

Dr. Karanas said, “My wife grew up in a small town in Upstate New York, and my first practice after residency was also in a small town. We are really excited to be back in a smaller town. We are enjoying learning about Jefferson City and have noticed people are very friendly and welcoming to us.”

Dr. Karanas said he tries to put patients at ease by not rushing them and explaining options slowly and carefully. “My goal is to be thoughtful with patients by giving people the time they need to ask questions and get comfortable with me as their physician.”

He offers a broad range of advanced laparoscopic procedures for abdominal surgery: gallbladder removal, hernia repair, appendix removal, and intestinal resections for various diseases. He also removes skin cancers, skin growths, and other soft tissue lesions that are too large for a dermatologist to take off as well as lesions and lumps underneath the skin. Laparoscopic or minimally invasive procedures are accomplished through smaller incisions, which means less pain and typically a faster recovery.

Dr. Karanas performs both inpatient and outpatient surgery at SSM Health St. Mary’s Hospital. His office is in the Multi Specialty Clinic in the Health Plaza on St. Mary’s Hospital campus at 2505 Mission Drive.


Andrew Karanas, MD, is a highly experienced board-certified general surgeon with SSM Health Medical Group, who specializes in minimally-invasive surgery and is known for his personal attention to patients.

SSM Health St. Mary’s Hospital: 2505 Mission Dr., Ste. 130, JCMO
(573) 681-3585 | ssmhealth.com/jc